Microsponges for controlled release and enhanced oral bioavailability of carbamazepine

The oral absorption and hence the bioavailability of carbamazepine (CBZ) is variable even after administration rapidly dissolving formulation. This problem was attributed to supersaturation CBZ transformation less soluble dihydrate (CBD). Accordingly, formulation sustained release products a promising approach overcome this problem. Microsponges are an emerging which can help in direction. aim work optimize composition microsponges for better encapsulation administration. were prepared using quasi emulsion solvent diffusion technique with varying ethyl cellulose polyvinyl alcohol (PVA). evaluated Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) X-ray diffraction. Production yield, entrapment efficiency surface morphology assessed addition drug release. Optimum administered orally albino rabbits evaluate reference unprocessed CBZ. Instrumental analysis reflected amorphous or molecularly dispersed form microsponges. size increased increasing polymer contents. associated reduction enhanced manifested by 2.6-fold increase area under plasma concentration versus time curve compared that study introduced as carriers delivery